IRD, Jaipur

Research & Publication

Awards

Dr Suresh Koolwal

1. Presidential oration award, Indian association of bronchology, Coimbatore, Feb 2018

2. Fellowship of Royal college of physicians, Edinburgh (FRCP)

3. Nominated as National President of Indian Association for Bronchology

Dr Sheetu Singh

1. Member of national academy of medical sciences

2. Assistant editor, Lung India

3. Editor, Lung Rajasthan

Research Work (Clinical trials - Principal Investigator – Dr. Narendra Khippal)

A) COPD - Principal investigator – Dr. Narendra Khippal

1. A Randomized, 26-Week, Placebo-Controlled Efficacy and Safety Study with a 2week Long-term Safety Extension of High and Medium-Dose Inhaled Mometasone Furoate/Formoterol Fixed-Dose Combination Formulation Compared with Formoterol and High-Dose Inhaled Mometasone Furoate Monotherapy in Subjects with Moderate to Severe COPD.

2. A randomized, double-blind, double dummy, multicentre, Parallel- group study comparing the efficacy and safety of the test HFA formulation of lpratropium bromide with the reference HFA formulation of lpratropium bromide in patients with mild or moderate chronic obstructive pulmonary disease (C0PD).

3. An open label comparative multicentric study to assess the efficacy and safety of fixed-dose combination of Formoterol fumarate & Mometasone furoate Dry Powder Inhaler (DPI) and fixed dose combination formoterol fumarate & Budesonide Dry Powder Inhaler {DPI) for the treatment of bronchial asthma and/or chronic obstructive pulmonary disease (COPD).

4. A randomised, double-blind, active-controlled parallel group study to evaluate the effect of 52 weeks of once daily treatment of orally inhaled tiotropium + olodaterol fixed dose combination compared with tiotropium on Chronic Obstructive Pulmonary Disease (COPD) exacerbation in patients with severe to very severe COPD.[DYNAGITO]

B) BRONCHIAL ASTHMA- Principal investigator –Dr. Narendra Khippal

5. An open label, comparative, multicentric study to assess the efficacy and safety of Zileuton extended-release tablets in comparison with Montelukast sodium tablets in patients suffering from bronchial asthma.

6. A phase II, 12 week randomized, double-blind, triple dummy, parallel group, placebo-controlled, dose range finding study to evaluate the safety, tolerability and efficacy of revamilast in subjects with chronic persistent Asthma.

7. A prospective, open label, non-comparative, observational, 24 weeks multicenter study of Fluticasone/Formoterol (Maxiflo®) FDC rotacaps (100/6 mcg and 250/6 mcg) when taken through Revolizer® in patients with persistent asthma.

C) ALLERGIC RHINITIS - Principal investigator – Dr. Narendra Khippal

8. A randomized, open label, comparative, multicentric study to assess the efficacy and safety of Acrivastine capsules in comparison with Chlorpheniramine maleate tablets in patients suffering from allergic rhinitis.

D) DEEP VEIN THROMBOSIS - Principal investigator – Dr. Narendra Khippal

1. International, multi-centre, randomized, double blind study to compare the overall mortality in acutely ill medical patients treated with enoxaparin versus placebo in addition to Graduated Elastic Stockings.

E) LUNG CANCER - Principal investigator – Dr. Narendra Khippal

1. A Randomized, double-blind, placebo controlled Phase 2 trial of Bavituximab plus Docetaxel in patients with previously treated locally Advanced or Metastatic Non­ Squamous Non-Small-Cell Lung Cancer.

2. A Randomized, open label, phase 2 trial of Paclitaxel/Carboplatin with or without Bavituzimab in patients with previously untreated locally Advanced or Metastatic Non-Squamous Non-Small-Cell Lung Cancer.

3. Phase 3 Study of Pemetrexed, Cisplatin, and Radiotherapy Followed by Consolidation Pemetrexed versus Etoposide, Cisplatin, and Radiotherapy Followed by Consolidation Cytotoxic Chemotherapy of Choice in Patients with Unresectable, Locally Advanced, Stage III Non-Small Cell Lung Cancer Other than Predominantly Squamous Cell Histology.

4. A phase III, multicenter, randomized, double-blind, unbalanced (3:1) active control study to assess the safety and describe the efficacy of netupitant and palonosetron for the prevention of chemotherapy-induced nausea and vomiting in repeated chemotherapy cycles.

F) Community acquired pneumonia -Principal investigator – Dr. Narendra Khippal

1. A Phase III, Multicentre, Randomized, Double-Blind, Comparative Study to Evaluate the Efficacy and Safety of Intravenous CeftarolineFosamil Versus Intravenous Ceftriaxone in the Treatment of Adult Hospitalised Patients With Community­Acquired Bacterial Pneumonia in Asia.

2. A Randomized, Double-blind, Double-dummy, Active-controlled, Multi-centre Trial to Compare the Efficacy and Safety of CSE-1034 (Ceftriaxone+ Sulbactam+ EOTA) with Meropenem in Infections Caused by -Lactamase (ESBL and MBL) producing Gram Negative Bacteria.

3. A Randomized, Multicentre, Double-blind, Double-dummy, Parallel-group Comparative Study to Determine the Efficacy, Safety And Tolerability of Ceftazidime-Avibactam (CAZ-AVI) Versus Meropenem in the Treatment of Nosocomial Pneumonia (NP) Including Ventilator-Associated Pneumonia (VAP) in Hospitalised Adults.

G) HIV - Principal investigator – Dr. Narendra Khippal

1. A prospective, multi-centre, double-blind, randomized, study to evaluate the safety and efficacy of Saroglitazar 4mg versus Placebo in the treatment of HIV associated lipodystrophy.

List of Publications till present

Dr Shashi Agnihotri

1.Bairwa Manish Kumar, Agnihotri S.P., Qureshi Mohammad J. charcterzation of microbiologial pattern in Brochiectasis patients Global Journal of Research analysis Vol.8 issue 2 Feb-2019

2. Gupta Rahul, Agnihotri S.P., Qureshi Mohammad J.  Correlation of Chest Computed tomography findings with six minute walk distance in people with post tubercular sequelae. Vol.8 issue 5, May, 2019

3. Ajith K., Singh A.K., Agnihotri S.P. “A study on Serum CRP and its Correlation with disease severity in stable COPD.” International Journal of Scientific research [IJSR 2020;9(2),56-58]

4. Gaur J.K., Singh A.K., Agnihotri S.P. “The changing Microbiological patterns of community acquired pneumonia.” Indian Journal of applied research Vol.10 issue 2, 51-52, Feb-2020.

5. Manish Kumar Meena, Aashish K. Singh, Shashi Prakash Agnihotri Corelation of 6 minute walk test with Clinico radiological parameters in stable COPD patients International Journal of Scientific research Vol.9 issue to February, 2020

Dr. Vinod Joshi

1. Mediastinal Aspergilloma: An unusual presentation as SVC obstruction. N Khippal, Anshika Jindal, Yogendra Rathore, Vinod Joshi, Shubhra Jain.The Egyption Journal of Chest Diseases and Tuberculosis. 2020, 69, 272-275  

Dr. Suresh Koolwal

1. ASSESSMENT OF INDICATORS OF MALNUTRITION IN COPD PATIENTS GLOBAL JOURNAL FOR RESEARCH ANALYSIS VOLUME-8, ISSUE-6, JUNE-2019 • PRINT ISSN No. 2277 – 8160

Dr Nalin Joshi

1. Joshi N. Systemic Scelrosis, Sine Scleroderma: An rare EMTY, Indian Journal of Chest Diseases & Allied sci.

Dr Chand Bhandari

Dr Shubhra Jain

1. Case report – Cryptogenic organizing pneumonia mimicking a mass lesion; An unusual case. Shubhra Jain, YogendraRathore, Anshika Jindal, Vinod Joshi Indian Journal Respiratory Care 2019, 8,124-6

2. Mediastinal Aspergilloma: An unusual presentation as SVC obstruction. N Khippal, Anshika Jindal, Yogendra Rathore, Vinod Joshi, Shubhra Jain. The Egyption Journal of Chest Diseases and Tuberculosis. 2020, 69,272-275

Dr. Sheetu Singh

1. Singh S, Collins BF, Bairwa M, Joshi JM, Talwar D, Singh N, Samaria JK, Mangal DK, Singh V, Raghu G. Hypersensitivity pneumonitis and its correlation with ambient air pollution in urban India. EurRespir J. 2019 Jan 31; 53(2). pii: 1801563.

2. Singh N, Singh S, Singh V. Learning curve: Endobronchial ultrasound-guided needle aspiration. Lung India 2019; 36:178-79.

3. Shekhar K, Bagarhatta R, Singh S, Sharma SK. Warfarin-induced diffuse alveolar hemorrhage: Case report and review of literature. Lung India 2019; 36:534-9.

4. Dhar R, Singh S, Talwar D, Mohan M, Tripathi SK, Swarnakar R, et al. Bronchiectasis in India: results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry. The Lancet Global Health. 2019;7(9):e1269-e79.

5. Mohan A, Madan K, Hadda V, Tiwari P, Mittal S, GuleriaR, Singh S, et al. Guidelines for diagnostic flexible bronchoscopy in adults: Joint Indian Chest Society/National College of chest physicians (I)/Indian association for bronchology recommendations. Lung India 2019;36(8):37-89.

6. Singh S, Collins BF, Sharma BB, Joshi JM, Talwar D, Katiyar S, et al. Hypersensitivity pneumonitis: Clinical manifestations – Prospective data from the interstitial lung disease‑India registry. Lung India 2019;36:476-82.

7. Sharma B, Singh S, Sharma K, Suraj K, Mahmood T, Samaria K, et al. Methodology of Seasonal Waves of Respiratory Disorders survey conducted at respiratory outpatient clinics across India. Lung India 2020;37(2):100-6.

8. Singh S, Sharma BB. Severe acute respiratory syndrome-coronavirus 2 and novel coronavirus disease 2019: An extraordinary pandemic. Lung India 2020;37(3):268-271.

9. Singh S, Sharma N, Singh U, Singh T, Mangal DK, Singh V. Rapid Systematic Review: Nasopharyngeal wash in preventing and treating upper respiratory tract infections: Could it prevent COVID-19? Lung India 2020;37(3):246-251.

10. Singh S, Sharma BB, Bairwa M, et al. Management of interstitial lung diseases: A consensus statement of the Indian Chest Society (ICS) and National College of Chest Physicians (NCCP). Lung India. 2020;37(4):359-378. 

Dr. Aashish Singh

1. Samaria M, Singh A.K., Joshi N. “Depression associated with multi drug resistant tuberculosis.”[GJRA 2019; 8(2),1-3].

2. Unchwal M, Singh A.K., Joshi N. “A Study on Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio with disease severity in stable and exacerbation of COPD.” [Paripex 2020;9(1),16-17]

3. Meena M, Singh A.K., Agnihotri S.P. “Correlation of 6 minute walk test with clinic-radiological parameters in stable COPD patients.” [IJSR 2020;9(2),48-49]

4. Ajith K., Singh A.K., Agnihotri S.P. “A study on Serum CRP and its Correlation with disease severity in stable COPD.” [IJSR 2020;9(2),56-58]

5. Gaur J.K., Singh A.K., Agnihotri S.P. “The changing Microbiological patterns of community acquired pneumonia.” [IJAR 2020;9(2),51-52]

6. Meena R.L., Singh A.K., Joshi N. “The Lactate-Albumin Ratio: a valuable tool for predicting outcome in Respiratory ICU patients.” [Paripex 2020;9(2),12-13]

7. Gupta S.K., Singh A.K., Meena A.S., Bajpai A. “A study to investigate the prevalence of metabolic and metabolic like syndrome in stable COPD patients.” [GJRA 2020;9(2),3-5]

8. Gupta S.K., Singh A.K..“A study to investigate the prevalence of metabolic syndrome in stable COPD patients.” [GJRA 2020;9(2),3-4]

Dr. Govind Singh Rajawat

1. Amardeepak Toppo, Gulabsingh Yadav, Govindsingh Rajawat, Thomas Kuriyan, Suresh koolwal Assessment Of Indicators Of Malnutrition In COPD Patients GJRA 2019 volume-8, issue-6, PRINT ISSN No. 2277 – 8160.

2. Bidyalakshmee Yumnam, Govind Singh Rajawat, Suresh Koolwal Assessment Of Inhalational Techniques And Changes Occurs After Imparting Education In Patients Of Obstructive Airway Diseases. VGjra 2019 Volume-8, Issue-4, Print Issn No. 2277 – 8160.

3. Govind Singh Rajawat, Mohammed JavedQureshi, Gulab Singh Yadav, Yumnam Bidyalakshmee, Suresh Koolwal, ManoharLal Gupta. Identifying the Factors Increasing the Yield of Closed Pleural Biopsy in Undiagnosed Exudative Pleural Effusion, The RMJ Issue Jan 2019 ISSN: 0485-9561Issue : Jan 2019; 19-22.

Dr Gulab Singh Yadav

1. Study of various reason for Interruption of Antitubercular treatment in patients of tuberculosis reporting to tertiary care center of West Rajasthan. International Journal of Research in Medical Science /June 2019/Vol. 7/Issue 6/ Page 2220

2. Assessments of Indicators of Malnutrition in COPD patients. Global Journal for Research Analysis. Vol.8/ Issue 6/ June 2019/ Print ISSN No. 2277-8160

Dr Mohammad Javed Qureshi

1. Bairwa Manish Kumar, Agnihotri S.P., Qureshi Mohammed J. charcterzation of microbiologial pattern in Brochiectasis patients Global Journal of Research analysis Vol.8 issue 2 Feb-2019

2.  Gupta Rahul, Agnihotri S.P., Qureshi Mohammed J. Correlation of Chest Computed tomography findings with six minute walk distance in people with post tubercular sequelae. Vol.8 issue 5, May, 2019

3. Identifying the Factors Increasing the Yield of Closed Pleural Biopsy in Undiagnosed Exudative Pleural Effusion Govind Singh Rajawat, Mohammed Javed Qureshi, Gulab Singh Yadav, Yumnam Bidyalakshmee, Suresh Koolwal, ManoharLal Gupta, (page.19) ISSN : 0485-9561 [Rajasthan medical journal]  Issue : Jan 2019

Dr. Manoj Meena